The Organic Acids Test is an advanced diagnostic tool that allows for the evaluation of the presence and concentration of organic acids in urine, with the objective of detecting and characterizing potential congenital metabolic errors and analyzing the status of various metabolic pathways in the body. This study provides a comprehensive view of cellular metabolism and can reveal underlying metabolic dysfunctions that impact overall health.

It includes the determination of more than 70 analytes related to the microbiota, the Krebs cycle, detoxification, and neurobiology, among others (compounds associated with amino acids, fatty acids, neurotransmitters, metabolites derived from the intestinal microbiota, markers of oxidative stress…).

The techniques used are LC-MS/MS, GC-MS, Ion Chromatography, and HPLC.

Test not suitable for patients under 3 years of age due to limitations associated with creatinine levels.

Bacterial OAs: indoleacetic, phenylacetic, o-hydroxyphenylacetic, p-hydroxyphenylacetic, p-hydroxybenzoic, benzoic, hippuric, 2-hydroxyhippuric, 4-hydroxyhippuric, paracresol, and HPHPA

Fungal OA: arabinose, arabinitol, tartaric, tricarballylic, citramalic, 5-hydroxymethyl-2-furoic, furan 2,5dicarboxylic, and furancarbonylglycine

Energetic OA: glucaric, pyruvic, lactic, citric, aconitic, isocitric, α-ketoglutaric, succinic, fumaric, malic, oxaloacetic, glyoxylic, glycolic, glyceric, oxalic, adipic, suberic, sebaceous, pimelic, β-hydroxybutyric, acetoacetic

Vitamins and Q10 OA: methylcitric, glutaric, xanthurenic, formaminoglutamic, malonic, methylmalonic, α-ketoisovaleric, hydracrylic, isovalerylglycine, dicrotalic, divalonic

Mineral OA: sodium, potassium, calcium, magnesium, iron, copper, zinc, cobalt, manganese, molybdenum, selenium

Detoxification OA: phenylglyoxylic, mandelic, hippuric, hexanoylglycine, α-hydroxybutyric, o-methylhippuric, p-methylhippuric + m-methylhippuric, orotic, glucaric, malonic, methylmalonic, pyroglutamic, 8-deoxyguanosine, cystathionine, cystine, citrulline, homocysteine, homocitrulline, cysteine sulfate, S-adenosylhomocysteine, taurine, methionine, ornithine, arginine, argininosuccinic, uric, antimony, arsenic, mercury, cadmium, lead

Neurological OAs: 2-hydroxyphenylacetic, tyrosine, phenylalanine, DOPA, DOPAC, homovanillic, vanilmandelic, xanthurenic, kynurenic, kynurenine, hydroxykynurenine, picolinic, quinolinic, tryptophan, 5-hydroxyindoleacetic, glutamine, glutamic, GABA, ethanolamine, phosphoetalonamine, 1-methylhistidine, 3-methylhistidine, histidine, glycine, serine, threonine, lithium, aluminum

Amino Acids OA: alanine, anserine, arginine, asparagine, aspartic, carnosine, isoleucine, leucine, lysine, proline, sarcosine, valine, α-methylglutaric, β-methylglutaric, α-hydroxyisovaleric, β-hydroxyisovaleric, α-hydroxyglutaric, p-hydroxyphenyllactic, dihydrocaffeic, β-phenyllactic, n-acetyl-aspartic, phenylpropionylglycine, β-methylcrotonylglycine, propionylglycine, tiglylglycine, suberylglycine, alpha-aminoadipic, beta-aminoisobutyric, hydroxylysine