Women’s Dysbiosis

Studies focused on the analysis of the microbiome and the identification of pathogens that can impact the health of the female reproductive system. Depending on the type of sample, we can study the vaginal or endometrial biofilm to evaluate if dysbiosis is present.

The balance of the vaginal microbiome can be altered by various factors, such as hormonal fluctuations, stress, medication, hygiene and eating habits, among others. Maintaining a healthy vaginal microbiome is essential not only to prevent infections, but also to preserve reproductive function and the correct development of the menstrual cycle. An imbalance in this microbiota can contribute to the development of vaginosis and affect a woman’s general health.

MICROBIOME by NGS:
Bacteriome: more than 50 bacterial genera are detected along with the most relevant species. The typing of the Lactobacillaceae family is included (L. crispatus, L. gasseri, L. jensenii, L. iners, L. paragasseri, L. vaginalis, etc.)
Mycobiome: 5 fungal genera are detected. The typing of the Candida group is included (C. albicans, C. auris, C. glabrata, C. krusei, C. parapsilosis, C. tropicalis, C. theae, C. utilis, C. dubliniensis, and C. lusitaniae)

PCR ITS: Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma parvum, Ureaplasma urealyticum, Lymphogranuloma venereum, Treponema pallidum, Haemophilus ducreyi.

PCR VIRUS: Herpes Simplex Virus 1, Herpes Simplex Virus 2, Cytomegalovirus, Varicella Zoster Virus.

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VAGINAL MARKERS: pH, secretory IgA, and Lactoferrin.

HPV GENOTYPING: High risk: 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68, 69, 73 and 82.
Low risk: 6, 11, 40, 42, 43, 44, 54, 61 and 70

LIQUID CYTOLOGY

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ENDOMETRIAL MARKERS:
Immunological: CD138, CD56, and BCL6.
Maturation: ER, PGR, and Ki67.