The Thyroid Plus Profile offers a systemic view of the thyroid axis (TSH, T3, and T4) and includes an expanded panel of vitamins and minerals, which allows for the detection of hormonal imbalances and nutritional status associated with the thyroid. It allows the identification of subclinical imbalances and modulating factors—inflammatory, metabolic, and nutritional—that influence clinical expression and response to treatment, facilitating personalized, etiological interventions aimed at functional optimization of the patient.